Frequency of Major Histocompatibility Antigens Class I in Mazandaran Province

Authors

Toghani Hulari, Fatemeh MSc in Immunology, Immunogenetics Research Center, Sari, Iran

Abediankenari, Saeid Professor, Immunogenetics Research Center, Mazandaran University of Medical Sciences, Sari, Iran

Akbari, Mohammad BSc in Medical Laboratory, Immunogenetics Research Center, Sari, Iran

Esmaili, Mozhgan MSc in Immunology, Immunogenetics Research Center, Sari, Iran

Khajenabi, Fatemeh MSc in Immunology, Immunogenetics Research Center, Sari, Iran

Abstract:

Background and purpose: Major histocompatibility antigens are the most polymorphic components of the immune system. The purpose of this study was to determine the frequency of human leukocyte antigens (HLA) in a population in Mazandaran province, Iran. Materials and methods: In a cross sectional study, peripheral blood samples were obtained from 550 people in Immunogenetics Research Center affiliated with Mazandaran University of Medical Sciences, 2016-2021. The types of HLA class 1 antigens (A-B-C) were studied using SSP-PCR. Results: HLA-A * 24, HLA-B * 35 and HLA-C * 04 were found to be the most common alleles in the population studied. Conclusion: HLA diversity plays a major role in developing some diseases. So, it should be investigated in anthropological studies and finding a suitable donor in bone marrow transplantation. In fact, more extensive studies are required to draw a new horizon in the association between HLA and diseases in different ethnicities.

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